SC 267 begins at an intersection with U.S. Route 15 (US 15; Bass Drive) south-southwest of Santee, within Orangeburg County.

It travels to the north-northwest and crosses over Providence Swamp before intersecting US 301 (Five Chop Road).

It crosses some railroad tracks and passes by, but does not enter, Lone Star.

It intersects the northern terminus of SC 33 (Cameron Road) northwest of Lone Star.

SC 267 crosses Squirrel Creek before meeting its northern terminus, an intersection with US 601 (Colonel Thomson Highway) southeast of Fort Motte, where the roadway continues as Adams Road.