The highway immediately travels through Sumter for approximately 60 feet (18 m) before re-entering Millwood.

It curves to the north-northwest and intersects U.S. Route 76 (US 76) and US 378 just southwest of Shaw Air Force Base.

[3] It curves to the north and north-northwest before traveling through a small portion of the base, with most turn-offs blocked by fences and/or jersey barriers.

It travels through rural areas of the county before it intersects Dubose Siding Road at Stanyarne Burrows Crossroad.

Then, it crosses over Cowpen Swamp and McGirts Creek before intersecting Red Hill Road in Hammetts Crossroads.

Two years later, its northern terminus was extended slightly, replacing part of SC 44 and ending at US 15.

Also, it was re-routed in Stateburg to replace SC 261 and travel to the south and south-southeast to end at US 76.