Stateburg is a census-designated place (CDP) in the High Hills of Santee in Sumter County, South Carolina, United States.

It is included in the Sumter, South Carolina Metropolitan Statistical Area.

Stateburg is located within a larger area in which many notable colonial & early South Carolinians owned homes to which they escaped the summertime malaria & other illnesses, High Hills of Santee.

In the 1780s, after the South Carolina General Assembly decided to move the state capital from Charleston to the central part of the state, Stateburg lost by only a few votes to Granby's Ferry, a small town on the Congaree River near the confluence of the Broad and Saluda rivers.

[5] Borough House Plantation and Church of the Holy Cross are listed on the National Register of Historic Places.