South Carolina Highway 50 (SC 50) was a state highway that existed in the central part of Orangeburg County.

It connected Cordova and Orangeburg.

SC 50 began at an intersection with U.S. Route 21 (US 21) and SC 5 (now Oakland Avenue) in Rock Hill.

It traveled to the east on Cedar Street, crossed over a railroad line, and traveled on Curtis Street to end at Mill Street.

The entire route was in Rock Hill, York County.