There are 11 Interstate Highways—5 primary and 6 auxiliary—that exist entirely or partially in the U.S. state of South Carolina.

As of December 31, 2013, the state had a total of 850.80 miles (1,369.23 km) of interstate and 11.80 miles (18.99 km) of interstate business, all maintained by the South Carolina Department of Transportation (SCDOT).

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