South Carolina Highway 555 (SC 555) is a 14.900-mile (23.979 km) primary state highway in the U.S. state of South Carolina.

It serves as an alternate route from downtown Columbia to Blythewood.

Before Interstate 77 (I-77) was completed in the area, SC 555 served as a major thoroughfare; today it is an alternate route.

[2] The highway was established in 1941 or 1942 as a new primary routing traveling from SC 12 to US 21.

Between 1948 and 1952, the highway was downgraded to secondary status until entire length was paved.