The state highway heads northeast as Maybank Highway, a two-lane road that passes by the Charleston Tea Plantation, the only working tea plantation in the United States, and near the Firefly Distillery, which is on Bear Bluff Road on the portion of the island north of Leadenwah Creek.

Main Road heads north from the junction through the northern part of the island before crossing the Stono River on the John F. Limehouse Memorial Bridge to meet US 17 between Rantowles and Charleston.

SC 700 continues east and near the eastern end of the island intersects River Road, which leads south to Charleston Executive Airport.

[2][3] SC 700 expands to four lanes and crosses Pennys Creek and the Stono River on the high-level Paul Gelegotis Bridge and enters James Island.

The highways enter the West Ashley section of Charleston by crossing Wappoo Creek, part of the Intracoastal Waterway, on a drawbridge named for Burnet R. Maybank.