South Carolina Highway 171 (SC 171) is a 12.560-mile (20.213 km) state highway located entirely within Charleston County in the U.S. state of South Carolina.

SC 171 begins at an intersection with Arctic Avenue in Folly Beach; the Folly Beach Fishing Pier and the Atlantic Ocean lie to the south.

The route heads north-northwest through Folly Beach's business district as Center Street.

After passing through a business district for 1.6 miles (2.6 km) the two highways separate, and SC 171 again heads northward.

The highway passes Charles Towne Landing, a state historic site and the location of the first permanent English settlement in the state, before merging into SC 7 at its northern terminus.