The Stono River or Creek is a tidal channel in southeast South Carolina, located southwest of Charleston.

[1][2] In 1725, Columbian mammoth teeth were excavated from the vicinity by African slaves, with the slaves correctly noting the resemblance to teeth of African elephants from their homeland.

Started by slaves from West Africa, likely from the Kingdom of Kongo, it became the largest slave uprising in the British mainland colonies prior to the American Revolution.

On June 20, 1779, it was also the site of the Battle of Stono Ferry during the American Revolution.

On January 30, 1863, as part of the American Civil War, a Confederate force captured the Union steamer USS Isaac Smith in which 8 men died and a further 17 were wounded in crossfire.