Many subdivisions in Greenville and Winterville fall in the districts for South Central High School, including: Westhaven, Cedar Ridge, Irish Creek, Starhill Farms, Signature Place, Ashley Meadows, Augusta Trails, Barefoot Landing, Barrington Fields, Baywood, Brook Hollow, Brighton Place and Canterbury.

South Central offers many classes that other schools do not, such as Japanese, Adobe, Digital Photography and African American History.

The sports department includes: Junior Varsity and Varsity teams of men's and women's basketball, soccer, tennis, swimming, cross country, track and field in addition to volleyball, wrestling, baseball, softball and cheerleading.

The Performing Arts department consists of classes such as band, orchestra, dance, and theater.

The theater classes perform skits and larger scale dramas throughout the course of the school year.