The S&CER line amalgamated in 1884 with the Swindon, Marlborough and Andover Railway to form the M&SWJR, and through services beyond Cirencester to the junction at Andoversford with the Great Western Railway's Cheltenham Lansdown to Banbury line, which had opened in 1881, started in 1891.

In 1905, the Great Western Railway's Minety station on the Swindon to Kemble line was renamed "Minety and Ashton Keynes": it was about the same distance south west of Ashton Keynes.

Passenger traffic at the station was never high, but there was much goods activity associated with the local gravel pits.

As a whole, traffic on the M&SWJR fell steeply after the Second World War and the line closed to passengers in 1961,[1] with goods facilities at South Cerney being withdrawn in July 1963.

The only traces of the station remaining are the line of the track through the railway arches and part of the Signal Box in the garden of Ashmoon House.