South Dakota Highway 52 (SD 52) is a state route that runs just north of the Missouri River, across southeast South Dakota.

It begins at a junction with South Dakota Highway 37 north of Springfield, and terminates in Yankton at U.S. Highway 81, at the junction of 4th and Broadway Streets.

The first SD 52 was located in the southwest portion of the state, designated in the mid-1920s.

It began at U.S. 18 in Edgemont, and ran southerly to meet what is now South Dakota Highway 71 near Rumford.

This road was renumbered as South Dakota Highway 471 in 1976.