The South Grand River is a stream in Bates, Cass, Henry and Benton counties of west central Missouri.
The stream headwaters are in Cass County at the confluence of Massey Creek and East Creek at 38°40′03″N 94°31′56″W / 38.66750°N 94.53222°W / 38.66750; -94.53222 three miles east of Cleveland and five miles southwest of Peculiar.
Just to the southeast of Archie the stream turns to the east and becomes the boundary between Cass and Bates counties.
The stream flows east through the Settles Ford Conservation Area and enters Henry County and passes south of Urich and Missouri Route 7.
The stream course continues as part of the lake passing under Missouri Route 13 south of Clinton and east into Benton County to its confluence with the Osage River one mile north of the Harry S Truman Dam at 38°16′35″N 93°24′42″W / 38.27639°N 93.41167°W / 38.27639; -93.41167.