South Henderson is a census-designated place (CDP) in Vance County, North Carolina, United States.

According to the United States Census Bureau, the CDP has a total area of 1.9 square miles (5.0 km2), all land.

As of the census[3] of 2000, there were 1,220 people, 452 households, and 321 families residing in the CDP.

There were 505 housing units at an average density of 260.7 per square mile (100.7/km2).

24.1% of all households were made up of individuals, and 9.1% had someone living alone who was 65 years of age or older.