South Hill is a town in Mecklenburg County, Virginia, United States.

Located on major Interstate and U.S. highways, it has a full-service hospital (serving patients from several rural counties), a tobacco market, and several hotels.

South Hill has a close relationship with the neighboring town of La Crosse.

Kerr Lake, a large reservoir popular with boaters and fishermen, is a short distance to the southwest.

In 2007–2008, contributions to presidential campaigns favored Republican candidates overall, although the top single recipient as of March was Democratic Senator Barack Obama.

The 283 South Hill voters who participated in the state's February 12 Democratic primary also favored Obama over Senator Hillary Clinton, 58% to 41%;[12] the 244 Republican primary voters supported Senator John McCain (62.3%) over Governor Mike Huckabee (34.8%).