South Italy (Italian: Italia meridionale or Sud Italia) is one of the five official statistical regions of Italy used by the National Institute of Statistics (ISTAT), a first level NUTS region and a European Parliament constituency.

It should not be confused with the Mezzogiorno, or southern Italy, which refers to the areas of the former Kingdom of the Two Sicilies (once including the southern half of the Italian peninsula and Sicily) with the usual addition of the Western Mediterranean island of Sardinia.

The latter and Sicily form a distinct statistical region, called Insular Italy.

[1] Below is the list of the population residing in 2022 in municipalities with more than 50,000 inhabitants:[1] The gross domestic product (GDP) of the region was 271.1 billion euro in 2018, accounting for 15.4% of Italy's economic output.

The GDP per capita adjusted for purchasing power was 19,300 euro, or 64% of the EU27 average in the same year.