Service at the station began on June 22, 2003 as part of the BART San Mateo County Extension project that extended BART service southward from Colma to Millbrae and San Francisco International Airport.

As of 2024[update], BART indicates "significant market, local support, and/or implementation barriers" that must be overcome to allow transit-oriented development on the surface parking lots at the station.

Route 35 stops at the corner of Mission Road and Evergreen Drive on the east side of the station.

[4] The city-operated South City Shuttle Blue and Green routes also uses the east busway.

[5] Media related to South San Francisco station (BART) at Wikimedia Commons