The creek is a tributary to Arroyo de la Laguna, flowing in the western Livermore Valley through Dublin and Pleasanton.

South San Ramon Creek drains the land area generally lying above the Bishop Subbasin of the Livermore Valley Groundwater Basin.

[3] The Bishop Subbasin lies entirely within Contra Costa County, is drained by, and is a portion of that area locally designated as San Ramon Valley.

The creek is being actively protected as of 2007, by the city of San Ramon[4] and other entities to preserve riparian zone habitat.

The public Iron Horse Regional Trail runs along a portion of South San Ramon Creek.