South Wayne is a village in Lafayette County, Wisconsin, United States.

[6] According to the United States Census Bureau, the village has a total area of 0.79 square miles (2.05 km2), all of it land.

There were 220 housing units at an average density of 278.5 per square mile (107.5/km2).

The racial makeup of the village was 99.2% White, 0.6% African American, and 0.2% from other races.

35.9% of all households were made up of individuals, and 17.5% had someone living alone who was 65 years of age or older.

33.0% of all households were made up of individuals, and 20.2% had someone living alone who was 65 years of age or older.