The board is committed to promoting economic development and quality of life in the Southern United States through innovations in energy and the environment.
Constituent members include Alabama, Arkansas, Florida, Georgia, Kentucky, Louisiana, Maryland, Mississippi, Missouri, North Carolina, Oklahoma, Puerto Rico, South Carolina, Tennessee, Texas, United States Virgin Islands, Virginia, and West Virginia.
The agreement led to Florida Governor LeRoy Collins convening a preliminary energy conference on January 25, 1956 in Oak Ridge, Tennessee.
These efforts resulted in the creation of a Regional Advisory Council on Nuclear Energy (RACNE), which first convened in Atlanta on February 1–2, 1957, with representatives from 14 states in attendance.
By September 1961, with eight states having ratified a proposed interstate compact, RACNE became the "Southern Interstate Nuclear Board" (SINB), the precursor to the SSEB, which then was officially sanctioned by enactment of Public Law 87-563, filed by Tennessee Senator Albert Gore Sr. and signed into law by President John F. Kennedy on July 31, 1962.