It takes the form of a surreal parody of talk shows, hosted by a reimagined version of the Hanna-Barbera character Space Ghost.

It contrasts the original 1960s series, Space Ghost, which aired as a standard Hanna-Barbera Saturday-morning superhero cartoon.

[3] It was revived on May 7, 2001, and was moved to the new Adult Swim late-night programming block on September 2, where new episodes premiered until April 12, 2004.

Space Ghost Coast to Coast helped launch the careers of the animators Adam Reed, Matt Thompson, Andy Merrill, Jim Fortier, Pete Smith, Michael Ouweleen, Erik Richter, Dave Willis, and Matt Maiellaro.

It produced the spin-offs The Brak Show, Aqua Teen Hunger Force, Perfect Hair Forever, and Harvey Birdman, Attorney at Law.

Although he starts out more level-headed and very much resembling his superhero ways, he becomes more and more eccentric, egomaniacal and idiotic with how he manages the show and treats his guests.

Space Ghost's bandleader, an evil talking mantis named Zorak, and his director-producer, a red-helmeted lava man named Moltar, work forced unpaid labor for Space Ghost, ostensibly as punishment for their crimes committed on the original series.

Because of their history as enemies of Space Ghost, they never get along with him even as co-workers and often make it very clear that they hate him and disrupt the show as retaliation for their forced labor.

Because of budget limitations, Ned Hastings recycled clips from the original series and reorganized them on an Avid non-linear editor for a "talk show" style program.

The characters' crudely animated lips, awkward movements that resembled "paper dolls glued to Popsicle sticks", and continuity errors became part of the joke.

Cartoon Network's Adult Swim often aired two 11-minute episodes back-to-back with advertisements to make a 30-minute programming block.

In the special, Space Ghost interviews a few of the new directors, while the Council of Doom members are the judges of the cartoon clips.

Space Ghost, Moltar, Zorak, Brak, and Mojo Jojo from The Powerpuff Girls appear in a 2002 interview with professional soccer player Hugo Sánchez on the Latin America Cartoon Network channel, and again in 2003 interviewing Óscar Pérez Rojas, which also features Eustace from Courage the Cowardly Dog.

The character is mentioned in the opening lyrics of cello rock band Rasputina's song "The Olde Headboard", which is featured on their 1998 album How We Quit the Forest.

Sidekicks Jan and Jace say that the two villains are clever and that once, to keep him from interfering in their plans, they even "hypnotized him into thinking he was a talk show host!

[24][25] The series, along with other Adult Swim shows such as Robot Chicken, Aqua Teen Hunger Force, Samurai Jack and Rick and Morty, was released on HBO Max on its May 2020 launch.

"$20.01", "Lovesick", "Transcript", "Sharrock", "Boo", "Freak Show", "Switcheroo", "Surprise", "Glen Campbell", "Jacksonville", "Late Show", "Cookout", "Art Show", and "Woody Allen's Fall Project" Special features include "Andy's Pilot", a performance by Thurston Moore, the unedited version of Matt Groening's interview from "Glen Campbell", pencil test footage, bonus footage and Easter eggs, as well as commentary on every episode.

"Rehearsal", "Gallagher", "Edelweiss", "Anniversary", "Zoltran", "Pilot", "Speck", "Zorak", "Switcheroo (1997 Version)", "Mayonnaise", "Brilliant Number One", "Boo Boo Kitty", "Needledrop", "Sphinx", "Pavement", "Untitled", "Hipster", "Piledriver", "Suckup", "Dam", "Boatshow", "Telethon", "Dimethylpyrimidinol Bisulfite" and "Joshua".

[28] It includes the episodes "Terminal", "Toast", "Lawsuit", "Cahill", "Warren" (36-minute cut), "Chinatown", "Rio Ghosto", "Pal Joey", "Curses", "Intense Patriotism" and "Waiting for Edward".

It includes the episodes "Snatch", "Sequel", "Girl Hair", "Chambraigne", "Table Read", "King Dead", "Fire Ant" (22-minute cut), "Curling Flower Space", "Knifin' Around", "The Justice Hole", "Kentucky Nightmare", "Sweet for Brak", "Flipmode", "Mommentary".

Extras include Snatch Alt Ending, Table Read Extra, Conan Raw Interview, George Lowe Record, Clay Croker Record, Promos, Busta Raw Interview, Momentary w/Creators Commentary and Momentary: Jelly Bean and two Easter eggs.

[29] A comedy album titled Space Ghost's Musical Bar-B-Que was released by Kid Rhino and Cartoon Network in 1997.