Clark Gregg reprises his role as Coulson from the film series, and is joined by series regulars Ming-Na Wen, Brett Dalton, Chloe Bennet, Iain De Caestecker, Elizabeth Henstridge, Henry Simmons, and Luke Mitchell.
"Spacetime" originally aired on ABC on April 5, 2016, and according to Nielsen Media Research, was watched by 2.81 million viewers.
Despite Leo Fitz's insistence that the future is fixed and Daisy's conviction that she must save Hinton, Coulson decides to instead send May.
Accompanied by Gideon Malick, Giyera and Hinton, the ancient Inhuman visits the Transia Corporation, massacres the board members, and retrieves a mechanized exoskeleton developed by the company.
Having promised Malick the "true power" he craves, the Inhuman convinces him to put on the exoskeleton, enhancing his strength.
find out about the attack on Transia and May prepares for the mission, Andrew Garner arrives and surrenders, explaining he is about to transform into Lash permanently.
Coulson convinces May to stay with Andrew and try to cure him with Jemma Simmons' previously-untested vaccine, which proves ineffective.
They are unsuccessful in their attempts to find the Inhuman, who escapes with Giyera, while Daisy pursues the fleeing Hydra agents to the roof in a bid to rescue Hinton, only to be attacked by Malick.
"[2] In March 2016, Marvel revealed that main cast members Clark Gregg, Ming-Na Wen, Brett Dalton, Chloe Bennet, Iain De Caestecker, Elizabeth Henstridge, Nick Blood, Adrianne Palicki, Henry Simmons, and Luke Mitchell would star as Phil Coulson, Melinda May, Grant Ward, Daisy Johnson, Leo Fitz, Jemma Simmons, Lance Hunter, Bobbi Morse, Alphonso "Mack" Mackenzie, and Lincoln Campbell, respectively.
[1] It was also revealed that the guest cast for the episode would include Blair Underwood as Andrew Garner, Matthew Willig as Lash, Powers Boothe as Gideon Malick, Mark Dacascos as Giyera, Alexander Wraith as Agent Anderson, Bjørn Johnson as Charles Hinton, Wolfgang Bodison as Edwin Abbott, Lola Glaudini as Polly Hinton, Markus Flanagan as Rowan Hamilton, Scott Broderick as officer, Matt Ferrucci as S.H.I.E.L.D.
On why the series' story needed the sequence, Tancharoen stated, "There has been such an arc from [Daisy] being a computer hacker to a supreme badass.