[3][1] The county was created December 20, 1851, and named for former United States representative and senator Thomas Spalding.

[4] Spalding County is included in the Atlanta-Sandy Springs-Roswell MSA.

The western portion of Spalding County, west of a line from Sunny Side through Griffin to Orchard Hill, is located in the Upper Flint River sub-basin of the ACF River Basin (Apalachicola-Chattahoochee-Flint River Basin).

[6] As of the 2020 United States census, there were 67,306 people, 25,339 households, and 16,563 families residing in the county.

Since then the closest a Democrat has been to winning Spalding County was in 1992 when Bill Clinton lost to George H. W. Bush by 5.6 percent.