The Fall Line Freeway runs across the southern portion of the county, following Georgia State Route 96 from Geneva to Junction City.

The southwestern quarter, west of Junction City, is located in the Middle Chattahoochee River-Walter F. George Lake sub-basin, while a narrow sliver of the western border, east of Waverly Hall, is located in the Middle Chattahoochee River-Lake Harding sub-basin.

[5] As of the 2020 United States census, there were 5,733 people, 2,809 households, and 1,849 families residing in the county.

The Talbot County School District holds pre-school to grade twelve, and consists of one building with 48 full-time teachers and 792 students.

Between 1880 and 2020, Talbot County has only voted Republican three times, although it also voted for American Independent segregationist George Wallace in 1968, Donald Trump's 39.50% in 2020 is the best number for a Republican since Nixon in the 1972 presidential election