It is located at 290 Magnolia Street, within walking distance of Wofford College, the Spartanburg County government administration building and the Donald S. Russell Federal Building, which includes the federal courthouse for the U.S. District Court for the District of South Carolina.

In 1915, a separate building, located west adjacent to station, was built for the Southern Express Company (packaging services).

In addition to serving the New Orleans-Washington-New York City corridor with six departures a day to Atlanta, the station hosted two trains a day on the Asheville to Columbia line with the (including the South Carolina section of the Carolina Special ran from Cincinnati to Knoxville, Asheville, Spartanburg, Columbia and finally to Charleston).

The Skyland Special ran from Asheville to Jacksonville, Florida, having a cessation from 1942 to 1947, owing to World War II.

[9] Located inside the depot building, the museum showcases Spartanburg's railroads and two major industries, textiles and peaches.