Located at 15 Wall Street (erroneously listed as 9 Main Street on the Amtrak timetable and the Amtrak official website), the station consists of a covered platform on the northwest side of the northeast-southwest tracks, a small parking lot, and a building.

The building is mostly boarded up, but it does have a small waiting room for Amtrak passengers.

Both the station and the freight house were originally built by the Charleston and Western Carolina Railway.

Both trains pass through Yemassee, near the growing towns of Beaufort and Hilton Head, at roughly the same times of the day; the northbound Palmetto and southbound Silver Meteor do so in the morning, while the southbound Palmetto and northbound Silver Meteor come through in the evening.

[2] The town is in the process of purchasing the station from Amtrak as part of a local revitalization effort.