3EAB, 3VFD668350850ENSG00000021574ENSMUSG00000024068Q9UBP0Q9QYY8NM_014946NM_199436NM_001363823NM_001363875NM_001377959NM_001162870NM_016962NM_001357738NP_055761NP_955468NP_001350752NP_001350804NP_001364888NP_001156342NP_058658NP_001344667The human gene SPAST codes for the microtubule-severing protein of the same name, commonly known as spastin.

[5] This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family.

Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis.

Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4 (SPG4).

[6] Spastic paraplegia Microtubule-associated protein This article on a gene on human chromosome 2 is a stub.