In 1994, Rice and Kenny Hotz, who had been friends since childhood, collaborated on the short film It Don't Cost Nothin' to Say Good Morning.

In 2000, Rice directed, produced and wrote a short film for TV entitled Something Anything which won a Telefest Independent Television Festival award for best comedy.

There was interest from the television station that had broadcast the short film and turn it into a TV series, but the idea was later scrapped.

In 2003, Rice and Hotz created the show Kenny vs. Spenny, which finished its sixth season in 2010 and ended with an hour-long series finale on December 23, 2010.

In 2008, Spencer Rice wrote and starred in the mockumentary film Confessions of a Porn Addict in which he played the character Mark Tobias.