Spider-Gwen explores a universe where Gwen Stacy was bitten by the radioactive spider instead of Peter Parker, leading her to a career as the Spider-Woman of her world.

[1][2] In October, Nick Lowe announced at New York Comic Con 2014 that the fan-favorite Spider-Gwen who was introduced in "Spider-Verse" would be getting her own series after much demand.

[5] Following the departure of Latour and Rodriguez, Marvel launched a new series titled Spider-Gwen: Ghost-Spider, written by Seanan McGuire with pencils by Rosi Kämpe, and later Takeshi Miyazawa.

Under this creative team, stories featured Gwen Stacy traveling back and forth between her home dimension, in which her identity was publicly known, and Earth-616, in which she attends college.

In 2022, a new limited series titled Spider-Gwen: Gwen-Verse by Tim Seeley and Jodi Nishijima was published, featuring Stacy traveling through time alongside alternative versions of herself (modeled after other Marvel heroes) to correct a disruption in the timeline.

She runs from the scene, creating the public misconception that Spider-Woman has murdered Peter Parker and is a menace to society and setting up the Spider-Gwen series.

Upon hearing about this, the Kingpin, one of New York's most prominent crime bosses, decides to ally himself with Spider-Gwen—for reasons unexplained—and apparently has his lawyer Matt Murdock (Daredevil on Earth-616, the main Marvel universe) send the assassin Aleksei Sytsevich to kill Captain Stacy.

Castle eventually makes the connection with Spider-Woman's identity and enlists the help of Kraven the Hunter to perform a siege on the Stacy house.

After a quick chat with Jessica Drew of Earth-616, Gwen and the Mary Janes go on a camping trip where Harry Osborn makes a surprise appearance.

While there, she is attacked by Frank Castle, and left with no other choice, uses one of her power-ups to take him down, before fleeing the scene, and spending the night at her father's place.

During the fight, Gwen's device is damaged by Kraven, and although she and her father escape, Frank Castle makes off with one of her six remaining power-ups.

In an intense fight, Frank Castle manages to escape, and after coming to her aid, Gwen's father turns himself in for assisting Spider-Woman.

"[19] Comic Book Resources said that the first issue was "fun, familiar, energetic and invigorating, the art is engaging and the character has nothing but potential to offer.