The Spire City Ghost Hounds are an inactive professional baseball team based in Frederick, Maryland, that played in 2023.

The franchise competed in the South Division of the Atlantic League of Professional Baseball and played home games at Nymeo Field at Harry Grove Stadium, sharing the ballpark with the Frederick Keys.

[5] The team held a name-the-team contest in January and February 2023, with the name to be announced in June 2023 from the choices of Bone Shakers, Ghost Hounds, Rail Frogs, Sawbones, and Screaming Alpacas.

[6] The team name was announced as Spire City Ghost Hounds on June 24.

[14] The team's 2023 front office staff was Chuck Domino, Senior Vice President of Baseball Operations, and Mary Nixon, executive director of Baseball Operations.