Spittal-on-Rule is a farm in the council area of Scottish Borders in Scotland.

More specifically, it lies where Rule Water meets the River Teviot.

The name Spittal means 'hospital'; this was the location of a medieval leprosy hospital, as well as a chapel and graveyard.

Before the existence of this hospital, the place was known as Rulemouth.

[1] Several old maps and documents suggest that the chapel was located directly above a well.