It serves as a service stop for the Amtrak Empire Builder, as well as the FlixBus, Greyhound, Trailways, and Jefferson Lines station for Spokane.

The Empire Builder provides service daily between Chicago, Illinois and Spokane before continuing on to Seattle, Washington or Portland, Oregon.

The eastbound trains join in Spokane in the middle of the night and run combined to Chicago Union Station.

In pre-Amtrak days, the Empire Builder split into Seattle and Portland sections at Spokane for most of the 1940s and 1950s.

The station, parking lot, and passenger platform are owned by the City of Spokane.