The spouse of the prime minister of Cambodia refers to the wife or husband of the head of government of the Kingdom of Cambodia, the Prime Minister.

Since 1993, 3 women have been the spouse of the Prime Minister of Cambodia.

The spouse of the current prime minister is Pich Chanmony.

The spouse of the prime minister of Cambodia frequently participates in humanitarian and charitable work as well as representing the prime minister.

The incumbent Bun Rany holds the position of President of the Cambodian Red Cross.