Spring Branch serves 35,000 kindergarten through 12th grade students and includes a region with 188,000 residents.

The Spring Branch ISD area is served by the Houston Community College System, but it is not within the tax base.

[5] The area did not become urban until the expansion of Houston city limits in the 1950s, which followed a failed attempt by the entire Spring Branch region to incorporate into a single entity, leading to the establishment of the Memorial Villages.

During Guthrie's term, an influx of Hispanic and low income students entered the district.

Melanie Markley of the Houston Chronicle wrote that Guthrie "not only guided the district back to health, but his retirement this year caps the end of a career that many say has earned Spring Branch a reputation as a trailblazer.

[10] In 2015 two sections of Thornwood, two and three, currently served by the Katy Independent School District, proposed being removed from Katy ISD and placed in Spring Branch ISD, but both KISD and SBISD's boards denied the proposal.

[11] Spring Branch ISD is led by a Superintendent of Schools, Dr. Jennifer Blaine, Ed.D., chosen by the Board of Trustees, headed by President Chris Earnest.

In 2023 the board of education began requiring students to use restroom facilities for the gender they were assigned at birth.