Spring Run is a tributary of Solomon Creek in Luzerne County, Pennsylvania, in the United States.

Spring Run begins in Wilkes-Barre, near Pennsylvania Route 309 and nor far from the village of Georgetown.

After several tenths of a mile, it turns west-southwest, exiting Wilkes-Barre and entering Hanover Township.

[1] Spring Run joins Solomon Creek 3.82 miles (6.15 km) upstream of its mouth.

[3] The entire length of Spring Run is considered by the Pennsylvania Department of Environmental Protection to be impaired.

The abandoned mine drainage in the watershed has caused the stream to have a low pH and high levels of suspended solids.

[4] The concentration of iron in the waters of Spring Run is 3.30 milligrams per liter and the daily load is 128.3 pounds (58.2 kg).

The aluminum concentration is 0.69 milligrams per liter and the daily load is 26.8 pounds (12.2 kg) per day.

[1] In the total maximum daily load document for Solomon Creek, Spring Run is described as being a small stream.

[2] The mouth of the stream is in the United States Geological Survey quadrangle of Wilkes-Barre West.

[5] Pennsylvania Route 309 and Interstate 81 pass through the watershed of Spring Run in an east-to-west direction.

[3] A prestressed box beam bridge carrying South Empire Street over Spring Run was constructed in 1972.

[3] Twenty percent of the macroinvertebrate taxa inhabiting Spring Run are of the orders Ephemeroptera, Plecoptera, and Trichoptera.