Spyridium waterhousei is a species of flowering plant in the family Rhamnaceae and is endemic to Kangaroo Island in South Australia.

It is an erect, slightly sticky shrub with linear leaves and heads of hairy flowers with three brown bracts at the base.

Spyridium waterhousei is an erect, slightly sticky shrub that typically grows to a height of up to 5 m (16 ft).

[2][3][4] Spyridium waterhousei was first formally described in 1862 by Ferdinand von Mueller in Fragmenta Phytographiae Australiae, from specimens collected on the "Freestone Range" by Frederick George Waterhouse.

[4] Spyridium waterhousei is endemic to Kangaroo Island in South Australia where it is known as Cryptandra waterhousii,[3] and grows in sugar gum (Eucalyptus cladocalyx) woodland, often along creeklines.