Because of the Fall of the Republic of Venice, Sperantzas brought the Heptanese School into the Greek Romantic period.

By the 1800s the Ionian Islands were occupied by both French and English forces and for the first time since the fall of the Byzantine Empire, the local Greeks governed themselves.

He also painted the iconostasis of the Greek Orthodox Church of San Nicolò dei Greci.

[7][8] Sperantzas and his son Michael brought the refined art of Corfu and the Heptanese School to Trieste.

He fortifies a stylistic transition in Greek art that evolved from the Cretan Renaissance to the Heptanese School.

Greek art was influenced by the Venetian Style and later evolved due to the exposure of English, French, and Austrian cultures.