The recipient of a Guggenheim Prize for Greece (in 1960), Spyros Vassiliou's works have been exhibited in galleries throughout Europe, in the United States, and Canada.

In 1929, Vassiliou held his first individual exhibition, and in 1930 he was awarded the Benaki Prize for his design of Saint Dionysios Church in Kolonaki, Athens.

With oils and watercolours, he painted natural and urban space, portraits, still-life, and scenes of daily living, combining selective elements of cubism and impressionism.

Well known projects include Michalis Kakoyiannis' 1962 adaptation of Euripides, and Elektra, starring Irene Papas and close friend Manos Katrakis.

The building is located blocks away from the ancient Odeon of Herodes Atticus, and the Acropolis of Athens but has closed its operation as a museum since February 2016.