The series was eventually collected as the trade paperback Squee's Wonderful Big Giant Book of Unspeakable Horrors.

An introverted and bullied little kid with a less than supportive family, Squee has been forced to mature a bit more quickly than his peers.

Squee's mother is addicted to some form of pill and spends a lot of time lying around in a nearly incoherent state.

His grandfather claims to keep healthy and young by consuming his children's first-borns, and subsequently attempts to devour Squee, only to reveal in horrifying fashion that he is in fact a cyborg and quite possibly insane.

Squee has only one friend, albeit a possibly imaginary one, the dilapidated teddy bear affectionately referred to as Shmee.

During the course of the series, Squee encounters a killer chihuahua (that fatally mauls the only classmate who was friendly to him), zombified classmates, sporting mishaps, alien abductions, near recruitment into Satan's army, an encounter with his future self, a ghostly visitor, a giant murderous dust mite and eventual committal to a mental institution despite being one of the most sane characters in the comic.

These experiences lead him to remark to a "lamb-baby-dog-thing" in one strip that some bitter cartoonist must be drawing his life and therefore he doesn't want to get too attached to anyone or anything in it.

This early, slightly different design of Pepito can be seen holding the hand of his mother in the panel in which Devi recalls the day she saw Nny at the bookstore.

Squee secretly agrees with Pepito's apocalyptic rantings, but isn't quite sure those who have taunted or hurt him in his life really deserve to be punished.

After inviting Squee over for dinner one night, Pepito professes his boredom with the human world, and complains to his father, Satan, that he has no one to play with in this "infernal inferno".

Shmee claims to be a "trauma sponge", soaking up all the negative feelings and experiences and storing them inside himself for Squee.

Squee is once again approached by the first pair of aliens who attempted to abduct him in issue 1, this time he manages to convince them that it would be smarter for them to take his parents, which they agree to.

He stated at the 2006 New York Comic Con that the scene where the chihuahua mauls Squee's friend was based on a similar thing that happened to him.