In addition, Mercy Hospital South operates four urgent care facilities located in Arnold, Fenton, Kirkwood, and Lemay.

In 1900, the Franciscan Sisters, Daughters of the Sacred Hearts of Jesus and Mary, based in Wheaton, Illinois, opened St. Anthony's Hospital at Grand and Chippewa in south St. Louis City.

The facility was named after Anthony of Padua, an early disciple of Francis of Assisi, who patterned his life and healing ministry after the example set by Jesus Christ.

In 1947, convalescent children who had survived polio under the auspices of the NFIP—later known as the March of Dimes—and its city and county chapters were brought to this hospital.

[4] Eventually, St. Anthony's grew weary of paying for physicians and services that didn't directly impact its campus and withdrew from Unity in 1999.

[6] In 1998, Russell de Greeff was diagnosed with terminal cancer and was admitted to St. Anthony's Medical Center.