[2] In 1963, the hospital's current location was founded in Creve Coeur, Missouri.

Since then, it has expanded, treating patients in the St. Louis region and other parts of Missouri.

In 2018, Mercy Hospital announced plans to open ten primary health care facilities in the St. Louis Metropolitan Area, along with 20 urgent health care centers.

[3] In 2020, the first coronavirus patient in Missouri, a Washington University student returning from Italy, was quarantined at Mercy Hospital.

[6] It has a HIMSS State 7 Ranking, making it one of the most technologically advanced hospitals in the country, with an extensive electronic health care system.