Established in 1931 as a school belonging to the local Roman Catholic parish of the same name which is in turn under the ecclesiastical purview of the Diocese of Penang, the school was transferred to the De La Salle Brothers after the Second World War and has remained part of the Lasallian community since.

Michel Bonamy;[1] started a school in a wooden shack adjoining the church building to cater to the needs of the Catholic children in his parish.

The first block of six classrooms was built on this land and officially opened by the British Resident of Perak, Marcus Rex, on 27 January 1941.

The school remained closed until the Surrender of Japan ended the hostilities of the Second World War and Malaya came under the British Military Administration.

Edmond sought to re-open the school but was hampered by a severe shortage of funds and manpower.

Edmond suggested that the Lasallian Brothers assume the administration and oversight of the school.

The Independence period saw stewardship of the school passed on to the former Director of St. Michael's Institution, the Rev.

Alban's stewardship, a three-acre site was acquired in Jalan Sungai Nibong and a new campus was built on that location to house the Primary School.

It was also in this period that further reforms in the Malaysian education system hastened the end of the Lasallian Brothers direct administration of the school.

[4] This was preceded by the closure of the two church run Teachers' Colleges after they were deaccredited by the Ministry of Education resulting in the lack of suitable candidates for direct hiring by mission schools.

St. Anthony's School remains a highly regarded institution in Teluk Intan.

Student participation in co-curricular activities are encouraged with points for participation being allocated for the total tariff calculated by the Bahagian Pengurusan Kemasukan Pelajaran (English: Education Admissions Management Division) for admissions into public universities.

The Anthonian Band is an institution in Teluk Intan and is constantly in demand for public functions.

Other uniformed organisations like the Scouts, the St. John Ambulance of Malaysia, the Malaysian Red Crescent Society and the Boys' Brigade are well represented in the school.

Students, faculty members as well as alumni of the school have been frequent participants in events organised by the Lasallian East Asian District (LEAD).