St. Columba's Hospital (Irish: Ospidéal Naomh Colm Cille) is a former psychiatric hospital in Sligo, County Sligo, Ireland.

The hospital, which was designed by William Deane Butler in the Elizabethan-style, opened as the Sligo Asylum in 1855.

[1] It became Sligo Mental Hospital in the 1920s and went on to become St. Columba's Hospital in the 1950s.

[1] After the introduction of deinstitutionalisation in the late 1980s the hospital went into a period of decline[2][3] and closed in 1992.

[4] After being converted for hotel use, it re-opened as the Clarion Hotel in 2005[4] and was subsequently re-branded as the Clayton Hotel.