It is located at 2975 Riverside Drive just east of Mooney's Bay, south of the Hog's Back Falls.

They originally worshiped in a church downtown, that is today St. Elijah's Housing.

In part due to the Lebanese Civil War the Antiochian Eastern-Orthodox population of Ottawa increased dramatically in the 1970s and 1980s and the congregation began to look for a larger home.

The Diocese of Ottawa today covers Eastern Canada and Upstate New York.

The cathedral has many active groups including the Sunday School, Teen SOYO youth group, Young Adults Ministry, the Fellowship of St. John the Divine, and the Antiochian Women.