St. George Regional is the major medical referral center for northwestern Arizona, southeastern Nevada and southern Utah.

The former Dixie Pioneer Memorial Hospital, which was built on the west half of the current 400 East campus, was eventually torn down to make way for later expansion of medical facilities.

[5][6] After twenty more years of growth within the region, the county residents once again approved funding for additional medical facilities.

[7] In 1975, The Church of Jesus Christ of Latter-day Saints divested itself of its hospitals and turned over ownership and operation to a newly formed nonprofit organization.

In the months that followed the opening of the new Dixie Medical Center, Washington County arranged for the sale of its new hospital to IHC for $2.65 million (equivalent to $14,200,000 in 2023).

[11] Intermountain believed it was affecting the recruitment of doctors, nurses, and other staff that did not understand local use of the term "Dixie.

Healthcare in southern Utah advanced to a new level as the first tertiary service, open-heart surgery, was performed on 2 December 2003.

[1] Southern Utah's first Acute Rehabilitation Center, which providing specialty care for stroke and other neurologically impaired patients, opened on the newly remodeled 5th Floor, December 26, 2003.