Built in the late nineteenth century, it remains the home of a functioning congregation, and it has been recognized as a historically significant building because of its architecture.

[3]: 196  Served by the Missionaries of the Precious Blood, it was named for Henry II, who reigned as Holy Roman Emperor during the eleventh century.

[2] At that time, there were few Catholics in St. Henry and the surrounding Granville Township; consequently, the congregation's first church building (erected in 1840) was a small frame structure.

[3]: 226  Large rose windows illuminate the interior,[2] which features painted and frescoed walls; the distance from the floor to the apex of the ceiling vault is 62 feet (19 m).

A major renovation project in the 1970s led to significant changes in the sanctuary, including the removal of frescoes by Austrian-born artist, Joseph Vittur, statues and its High Gothic altar.,[2] designed by the E.Hackner Co., LaCrosse, WI.

[2] Two years later, the church was recognized for its architecture and its high quality of preservation when it was added to the National Register of Historic Places.