St. Joe High School was a comprehensive public high school serving students in grades seven through twelve in the remote, rural community of St. Joe, Arkansas, United States.

[3] This Title I school is accredited by the Arkansas Department of Education (ADE).

The assumed course of study follows the Smart Core curriculum developed the Arkansas Department of Education (ADE), which requires students to complete at least 22 credit units before graduation.

Students engage in regular (core) and career focus courses and exams and may select Advanced Placement (AP) coursework and exams that may lead to college credit.

The St. Joe Wildcats participate in various interscholastic activities in the 1A Classification—the state's smallest classification—within the 1A East Conference administered by the Arkansas Activities Association.