St. John the Baptist in the Wilderness is an oil painting on panel by the Netherlandish artist Hieronymus Bosch, created c. 1489.

The painting was acquired by the Spanish collector Lázaro Galdiano in 1913.

The painting forms a pair with St. John the Evangelist on Patmos which is in Berlin.

It has since been suggested that the altarpiece in question was an artwork which is known to have been made for St. John's Cathedral, 's-Hertogenbosch.

The animal is said to symbolise the sacrifice of the saint as an innocent victim of the wickedness of mankind,[2] or it could be that the saint is pointing towards Jesus Christ, whose symbol is the paschal lamb (John 1:29–36[3]).