It is part of the St. John's National Academy of Health Sciences run by the Catholic Bishops' Conference of India.

The college annually accepts 150 students for the MBBS undergraduate course based on a national entrance exam.

In 2018, St. John's Medical College partnered with Apple to conduct a needs assessment of the health and well-being of supplier employees.

Based on assessment findings, Apple developed and launched a training curriculum to improve health knowledge in key areas.

[citation needed] In December 1994, the Institution was renamed as St. John's National Academy of Health Sciences and it comprises the following Institutes: St John's Medical College was ranked 19th among medical colleges in India by the NIRF in 2023.