Formerly located adjacent to the campuses of the University of Notre Dame, St. Mary's College, and Holy Cross College, in 2012, the school moved to a new location about a mile south of Notre Dame.

Contributions from South Bend and Mishawaka parishioners enabled building the school on 5.7 acres (23,000 m2) of land donated to the Diocese of Fort Wayne-South Bend by the Brothers of Holy Cross.

From 1953 to 1968, Saint Joseph's High School had separate divisions for boys and girls.

St Joe has been named a Blue Ribbon school by the United States Department of Education.

[6] The Saint Joseph Indians are a member of the Northern Indiana Conference.